Optimal threshold for stromal tumor-infiltrating lymphocytes: its predictive and prognostic value in HER2-positive breast cancer treated with trastuzumab-based neoadjuvant chemotherapy

@article{Liu2015OptimalTF,
  title={Optimal threshold for stromal tumor-infiltrating lymphocytes: its predictive and prognostic value in HER2-positive breast cancer treated with trastuzumab-based neoadjuvant chemotherapy},
  author={Shiwei Liu and Xuening Duan and Ling Xu and Ling Xin and Yuanjia Cheng and Qian Liu and Jingming Ye and Shuang Zhang and Hong Zhang and Sainan Zhu and Ting Li and Yin-hua Liu},
  journal={Breast Cancer Research and Treatment},
  year={2015},
  volume={154},
  pages={239-249}
}
The purpose of the present study was to determine the optimal threshold for stromal tumor-infiltrating lymphocytes (TILs) and investigate its predictive and prognostic value in HER2-positive breast cancer treated with trastuzumab-based neoadjuvant chemotherapy (NAC). Levels of stromal TILs were evaluated using hematoxylin and eosin-stained sections of core biopsies from 116 patients. We investigated the correlation between stromal TILs and pathological response to identify its optimal threshold… CONTINUE READING
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