Optimal three-stage designs for phase II cancer clinical trials.

  • T. T. Chen
  • Published 1997 in Statistics in medicine


The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at the first stage. Ensign et al. extended two-stage optimal… (More)


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