Optimal tests for rare variant effects in sequencing association studies.


With development of massively parallel sequencing technologies, there is a substantial need for developing powerful rare variant association tests. Common approaches include burden and non-burden tests. Burden tests assume all rare variants in the target region have effects on the phenotype in the same direction and of similar magnitude. The recently… (More)
DOI: 10.1093/biostatistics/kxs014

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