Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1

@inproceedings{Ow2019OptimalTO,
  title={Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1},
  author={Thomas J. Ow and Cory D Fulcher and Carlos Thomas and Pilib {\'O} Broin and Andrea Vaca L{\'o}pez and Denis E. Reyna and Richard V. Smith and Catherine Sarta and Michael B. Prystowsky and Nicolas F Schlecht and Bradley A. Schiff and Gregory Rosenblatt and Thomas J. Belbin and Thomas Maxwell Harris and Geoffrey Childs and Nicole Kawachi and Chandan Guha and Evripidis Gavathiotis},
  booktitle={Oncotarget},
  year={2019}
}
Mechanisms of treatment resistance in head and neck squamous cell carcinoma (HNSCC) are not well characterized. In this study, HNSCC tumors from a cohort of prospectively enrolled subjects on an ongoing tissue banking study were divided into those that persisted or recurred locoregionally (n=23) and those that responded without recurrence (n=35). Gene expression was evaluated using llumina HumanHT-12-v3 Expression BeadChip microarrays. Sparse Partial Least Squares - Discriminant Analysis (sPLS… CONTINUE READING

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