Optimal sampling times for pharmacokinetic experiments

@article{DArgenio1981OptimalST,
  title={Optimal sampling times for pharmacokinetic experiments},
  author={David Z. D'Argenio},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1981},
  volume={9},
  pages={739-756}
}
A sequential estimation procedure is presented which uses optimal sampling times to estimate the parameters of a model from data obtained from a group of subjects. This optimal sampling sequential estimation procedure utilizes parameter estimates from previous subjects in the group to determine the optimal sampling times for the next subject. Parameter estimates obtained from the optimal sampling procedure are compared to those obtained from a conventional sampling scheme by using Monte Carlo… CONTINUE READING

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