Optimal sampling designs for accurate estimation of parasite clearance in the context of artemisinin resistance

@inproceedings{Flegg2012OptimalSD,
  title={Optimal sampling designs for accurate estimation of parasite clearance in the context of artemisinin resistance},
  author={Jennifer A. Flegg and Philippe J Guerin and François H Nosten and Arjen Mattheus Dondorp and Rick M. Fairhurst and Doung 7 Socheat and Steffen Borrmann and Anders B Bj{\"o}rkman and Andreas M{\aa}rtensson and Mayfong Mayxay and Paul Newton and Delia R. Bethell and Youry Se and Harald Noedl and Abdoulaye A. Djimd{\'e} and Nicholas J White and Kasia Stepniewska},
  booktitle={Malaria Journal},
  year={2012}
}
Background The emergence of artemisinin resistance in South East Asia threatens the efficacy of artemisinin derivatives (AD). Since the pharmacodynamic hallmark of AD is rapid parasite clearance, the clinical phenotype of slow clearance characterises resistance. This indicator remains critically important to monitor the extent of the problem in the absence of molecular marker(s) associated with artemisinin resistance and lack of sensitivity of current in vitro tests. Frequent parasite counts… CONTINUE READING