Optimal protein-folding codes from spin-glass theory.

  title={Optimal protein-folding codes from spin-glass theory.},
  author={Richard A. Goldstein and Zaida Luthey-Schulten and Peter G. Wolynes},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 11},
Protein-folding codes embodied in sequence-dependent energy functions can be optimized using spin-glass theory. Optimal folding codes for associative-memory Hamiltonians based on aligned sequences are deduced. A screening method based on these codes correctly recognizes protein structures in the "twilight zone" of sequence identity in the overwhelming majority of cases. Simulated annealing for the optimally encoded Hamiltonian generally leads to qualitatively correct structures. 

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