Optimal periodic control of a drug delivery system

Abstract

Administration of certain drugs at a steady rate results in deterioration of drug effect, also known as drug tolerance. Periodic delivery is an attractive option for minimizing tolerance and maximizing the desired effect of such drugs. In this paper, periodic drug infusion strategies for maximizing a time averaged measure of drug effect are investigated. A… (More)
DOI: 10.1016/j.compchemeng.2007.11.003

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