Optimal perfusion rate determined for in situ intestinal absorption studies in rats.

@article{Savina1981OptimalPR,
  title={Optimal perfusion rate determined for in situ intestinal absorption studies in rats.},
  author={Paul M. Savina and Alfred E. Staubus and Timothy S. Gaginella and Donald F. Smith},
  journal={Journal of pharmaceutical sciences},
  year={1981},
  volume={70 3},
  pages={239-43}
}
Iopanoic acid was used as a model compound to study the effect of the intestinal perfusion rate on the mean absorption clearance. Absorption of iopanoic acid followed first-order kinetics, with a first-order absorption rate constant (ka) linearly dependent on the dry intestinal weight. An absorption clearance--time plot revealed three phases. Phase I represented an equilibration phase, Phase II was a uniform phase, and Phase III was a physiological deterioration of the animal under prolonged… CONTINUE READING