Optimal path to epigenetic switching.

@article{Roma2005OptimalPT,
  title={Optimal path to epigenetic switching.},
  author={David Marin Roma and Ruadhan A. O'Flanagan and Andrei E. Ruckenstein and Anirvan M. Sengupta and Ranjan Mukhopadhyay},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  year={2005},
  volume={71 1 Pt 1},
  pages={011902}
}
We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation. 
Highly Cited
This paper has 49 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 15 references

Genetics 149

A. P. Arkin, J. Ross, H. H. McAdams
1633 • 1998
View 4 Excerpts
Highly Influenced

Genes Dev

I. B. Dodd, K. E. Shearwin, +3 authors J. B. Egan
18, 344 • 2004
View 3 Excerpts
Highly Influenced

Biophys

M. Santillan, M. C. Mackey
J. 86, 75 • 2004

Nature 422

W. J. Blake, M. Kærn, C. R. Cantor, J. J. Collins
633 • 2003
View 2 Excerpts

Proc

F. J. Isaacs, J. Hasty, C. R. Cantor, J. J. Collins
Natl. Acad. Sci. U. S. A. 100, 7714 • 2003

Science 297

M. B. Elowitz, A. J. Levine, E. D. Siggia, P. S. Swain
1183 • 2002
View 2 Excerpts

and A

E. M. Ozbudak, M. Thattai, I. Kurtser, A. D. Grossman
van Oudenaarden, Nat. Genet. 31, 69 • 2002
View 3 Excerpts

Nature 403

T. S. Gardner, C. R. Cantor, J. J. Collins
339 • 2000

Embo J

J. W. Little, D. P. Shepley, D. W Wert
18, 4299-4307 • 1999
View 2 Excerpts

Similar Papers

Loading similar papers…