Optimal path to epigenetic switching.

  title={Optimal path to epigenetic switching.},
  author={David Marin Roma and Ruadhan A. O'Flanagan and Andrei E. Ruckenstein and Anirvan M. Sengupta and Ranjan Mukhopadhyay},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={71 1 Pt 1},
We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation. 
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