Optimal nitrate therapy with a once-daily sustained-release formulation of isosorbide mononitrate.

  • Donald Waller
  • Published 1999 in Journal of cardiovascular pharmacology


During long-term prophylaxis of angina with oral nitrates, sustained high plasma nitrate concentrations produce partial or complete tolerance to both the haemodynamic and the clinical effects of the drug. There is substantial evidence that this can be prevented by an adequate nitrate-free or nitrate-low period during each 24 h dosing interval. However, a… (More)


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