Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons.

@article{Sanchez2009OptimalNB,
  title={Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons.},
  author={Pascal E. Sanchez and Raafat P. Fares and J Risso and Chantal Bonnet and Sandrine Bouvard and Marion Le-Cavorsin and B{\'e}atrice Georges and Colette Moulin and Amor Belmeguenai and Jacques Bodennec and Anne Morales and J N Pequignot and Etienne Emile Baulieu and Robert A. Levine and Laurent Bezin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 24},
  pages={9848-53}
}
Erythropoietin receptor (EpoR) binding mediates neuroprotection by endogenous Epo or by exogenous recombinant human (rh)Epo. The level of EpoR gene expression may determine tissue responsiveness to Epo. Thus, harnessing the neuroprotective power of Epo requires an understanding of the Epo-EpoR system and its regulation. We tested the hypothesis that neuronal expression of EpoR is required to achieve optimal neuroprotection by Epo. The ventral limbic region (VLR) in the rat brain was used… CONTINUE READING
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Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus

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