Optimal modeling for phase I design of a two drug combination—results of a phase I study of cisplatin with 9-nitrocamptothecin

@article{Lee2008OptimalMF,
  title={Optimal modeling for phase I design of a two drug combination—results of a phase I study of cisplatin with 9-nitrocamptothecin},
  author={S.-J. Lee and Mrinal M. Gounder and Eric H. Rubin and Jong Ming Li and Zheming Gu and Anu Thalasila and Evelyn M Loyer and Andrzej P. Kudelka and Claire F. Verschraegen},
  journal={Investigational New Drugs},
  year={2008},
  volume={26},
  pages={541-551}
}
Combination of platinum with topoisomerase-I inhibitors are synergistic. The objectives of this study were to determine MTD range and toxicity profile of combinations of oral 9-nitrocamptothecin (9NC) and intravenous cisplatin in patients with refractory solid tumors. Each course was 28 days starting on day 1 with cisplatin, and then 9NC daily for 5 days/week for three weeks. A new two arm crossing design was created: patients in arm 1 were treated with at the single agent recommended dose of… CONTINUE READING

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