Optimal linear combinations of multiple diagnostic biomarkers based on Youden index.

@article{Yin2014OptimalLC,
  title={Optimal linear combinations of multiple diagnostic biomarkers based on Youden index.},
  author={Jingjing Yin and L. Tian},
  journal={Statistics in medicine},
  year={2014},
  volume={33 8},
  pages={1426-40}
}
In practice, usually multiple biomarkers are measured on the same subject for disease diagnosis. Combining these biomarkers into a single score could improve diagnostic accuracy. Many researchers have addressed the problem of finding the optimal linear combination based on maximizing the area under ROC curve (AUC). Actually, such combined score might have less than optimal property at the diagnostic threshold. In this paper, we propose the idea of using Youden index as an objective function for… CONTINUE READING
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