Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies.

@article{Casciaro2010OptimalEC,
  title={Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies.},
  author={Sergio Casciaro and Francesco Conversano and Andrea Ragusa and Maria Ada Malvindi and Roberto Franchini and Antonio Greco and Teresa Pellegrino and Giuseppe Gigli},
  journal={Investigative radiology},
  year={2010},
  volume={45 11},
  pages={715-24}
}
OBJECTIVES To experimentally investigate the acoustical behavior of silica nanoparticles within conventional diagnostic ultrasound fields and to determine a suitable configuration, in terms of particle size and concentration, for their employment as targetable contrast agents. We also assessed the effectiveness of a novel method for automatic detection of targeted silica nanoparticles for future tissue typing applications. MATERIALS AND METHODS Silica nanospheres of variable size (160, 330… CONTINUE READING
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