Optimal drug combinations and minimal hitting sets

@article{Vazquez2009OptimalDC,
  title={Optimal drug combinations and minimal hitting sets},
  author={Alexei Vazquez},
  journal={BMC Systems Biology},
  year={2009},
  volume={3},
  pages={81 - 81}
}
Identifying effective drug combinations that significantly improve over single agents is a challenging problem. Pairwise combinations already represent a huge screening effort. Beyond two drug combinations the task seems unfeasible. In this work we introduce a method to uncover drug combinations with a putative effective response when presented to a heterogeneous population of malignant agents (strains), such as cancer cell lines or viruses. Using data quantifying the effect of single drugs… CONTINUE READING
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