Optimal designs for active controlled dose-finding trials with efficacy-toxicity outcomes.

@article{Schorning2017OptimalDF,
  title={Optimal designs for active controlled dose-finding trials with efficacy-toxicity outcomes.},
  author={Kirsten Schorning and Holger Dette and K. Kettelhake and Weng Kee Wong and Frank Bretz},
  journal={Biometrika},
  year={2017},
  volume={104 4},
  pages={1003-1010}
}
We derive optimal designs to estimate efficacy and toxicity in active controlled dose-finding trials when the bivariate continuous outcomes are described using nonlinear regression models. We determine upper bounds on the required number of different doses and provide conditions under which the boundary points of the design space are included in the optimal… CONTINUE READING