Optimal design for linear interpolation of curves.

  title={Optimal design for linear interpolation of curves.},
  author={Jixian Wang},
  journal={Statistics in medicine},
  volume={20 16},
Non-parametric procedures are often used for the analysis of pharmacokinetic trials. Fewer design procedures are available for non-parametric estimation than for parametric estimation. Linear interpolation is widely used for curve estimation in pharmacokinetic trials, where often only sparse sampling is feasible. Current design procedures for smoothing or local fit are not suitable as they are based on asymptotic properties and the bias of the estimate is ignored. This paper proposes optimal… CONTINUE READING

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