Optimal control strategies for disinfection of bacterial populations with persister and susceptible dynamics.


It is increasingly clear that bacteria manage to evade killing by antibiotics and antimicrobials in a variety of ways, including mutation, phenotypic variations, and formation of biofilms. With recent advances in understanding the dynamics of the tolerance mechanisms, there have been subsequent advances in understanding how to manipulate the bacterial… (More)
DOI: 10.1128/AAC.00675-12


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