Optimal control of malaria chemotherapy

  title={Optimal control of malaria chemotherapy},
  author={Gesham Magombedze and C. Chiyaka and Zindoga Mukandavire},
Abstract. We present an intra-host mathematical model of malaria that describes the interaction of the immune system with the blood stage malaria merozoites. The model is modified by incorporating the effects of malaria drugs that target blood stage parasites. The optimal control represents a percentage effect of the chemotherapy of chloroquine in combination with chlorpheniramine on the reproduction of merozoites in erythrocytes. First we maximise the benefit based on the immune cells, and… CONTINUE READING


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