Optimal control of gene expression for fast proteome adaptation to environmental change.

@article{Pavlov2013OptimalCO,
  title={Optimal control of gene expression for fast proteome adaptation to environmental change.},
  author={Michael Yu. Pavlov and M{\aa}ns Ehrenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 51},
  pages={20527-32}
}
Bacterial populations growing in a changing world must adjust their proteome composition in response to alterations in the environment. Rapid proteome responses to growth medium changes are expected to increase the average growth rate and fitness value of these populations. Little is known about the dynamics of proteome change, e.g., whether bacteria use optimal strategies of gene expression for rapid proteome adjustments and if there are lower bounds to the time of proteome adaptation in… CONTINUE READING

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Calculus of Variations and Optimal Control Theory (Princeton Univ Press, Princeton)

  • D Liberzon
  • 2011
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