Optimal cerebrospinal fluid magnesium ion concentration for vasodilatory effect and duration after intracisternal injection of magnesium sulfate solution in a canine subarachnoid hemorrhage model.

@article{Mori2011OptimalCF,
  title={Optimal cerebrospinal fluid magnesium ion concentration for vasodilatory effect and duration after intracisternal injection of magnesium sulfate solution in a canine subarachnoid hemorrhage model.},
  author={Kentaro T. Mori and Takeshi Yamamoto and Masahiro Miyazaki and Yasukazu Hara and Yasutaka Aiko and Nobuhiro Koike and Shinsuke H. Sakamoto and Yasuaki Nakao and Takanori Esaki},
  journal={Journal of neurosurgery},
  year={2011},
  volume={114 4},
  pages={
          1168-75
        }
}
OBJECT The optimal CSF Mg(++) concentration for vasodilation of spastic cerebral arteries after subarachnoid hemorrhage (SAH) and its duration are unknown. The temporal profile of the vasodilatory effect and optimal CSF Mg(++) concentration after the intracisternal injection of MgSO(4) solution were investigated in an SAH model in canines. METHODS Cerebral vasospasm was induced by experimental SAH using a 2-hemorrhage model in 26 female beagles. On Day 7, 0.5 ml/kg of 15, 10, 5, or 0 mmol/L… CONTINUE READING

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