Optimal and suboptimal protocols for a class of mathematical models of tumor anti-angiogenesis.

@article{Ledzewicz2008OptimalAS,
  title={Optimal and suboptimal protocols for a class of mathematical models of tumor anti-angiogenesis.},
  author={Urszula Ledzewicz and Heinz Sch{\"a}ttler},
  journal={Journal of theoretical biology},
  year={2008},
  volume={252 2},
  pages={295-312}
}
Tumor anti-angiogenesis is a cancer treatment approach that aims at preventing the primary tumor from developing its own vascular network needed for further growth. In this paper the problem of how to schedule an a priori given amount of angiogenic inhibitors in order to minimize the tumor volume is considered for three related mathematical formulations of a biologically validated model developed by Hahnfeldt et al. [1999. Tumor development under angiogenic signalling: a dynamical theory of… CONTINUE READING
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