Optimal adaptive designs for binary response trials.

  title={Optimal adaptive designs for binary response trials.},
  author={William F Rosenberger and Nigel Stallard and Anastasia Ivanova and Charles Neely Harper and Madia Ricks},
  volume={57 3},
We derive the optimal allocation between two treatments in a clinical trial based on the following optimality criterion: for fixed variance of the test statistic, what allocation minimizes the expected number of treatment failures? A sequential design is described that leads asymptotically to the optimal allocation and is compared with the randomized play-the-winner rule, sequential Neyman allocation, and equal allocation at similar power levels. We find that the sequential procedure generally… CONTINUE READING

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