• Biology
  • Published 2011

Optimal Therapy of Hepatitis C Dynamics and Sampling Based Analysis

@inproceedings{Pachpute2011OptimalTO,
  title={Optimal Therapy of Hepatitis C Dynamics and Sampling Based Analysis},
  author={Gaurav Pachpute and Siddhartha P. Chakrabarty},
  year={2011}
}
We examine two models for hepatitis C viral (HCV) dynamics, one for monotherapy with interferon (IFN) and the other for combination therapy with IFN and ribavirin. Optimal therapy for both the models is determined using the steepest gradient method, by defining an objective functional which minimizes the infected hepatocyte levels, virion population and the side-effects of the drug(s). The optimal therapy for both the models shows an initial period of high efficacy, followed by a gradual… CONTINUE READING

Figures and Tables from this paper.

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Mutation and control of the human immunodeficiency virus.

  • Mathematical biosciences
  • 2008
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Advances in the mathematical modelling o f hepatitis C virus dynamics

NM Dixit
  • Journal of the Indian Institute of Science
  • 2008
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Optimal control of hepatitis C antiviral treatment programme delivery for pre vention amongst a population of injecting drug

NK Martin, B Ashley, +3 authors M H ickman
  • users, PLos One,
  • 2011
VIEW 1 EXCERPT