Optimal Stimulus Shapes for Neuronal Excitation

  title={Optimal Stimulus Shapes for Neuronal Excitation},
  author={Daniel B. Forger and David Paydarfar and John R. Clay},
  booktitle={PLoS Computational Biology},
An important problem in neuronal computation is to discern how features of stimuli control the timing of action potentials. One aspect of this problem is to determine how an action potential, or spike, can be elicited with the least energy cost, e.g., a minimal amount of applied current. Here we show in the Hodgkin & Huxley model of the action potential and in experiments on squid giant axons that: 1) spike generation in a neuron can be highly discriminatory for stimulus shape and 2) the… CONTINUE READING
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