Optimal N-ethyl-N-nitrosourea (ENU) doses for inbred mouse strains.

  title={Optimal N-ethyl-N-nitrosourea (ENU) doses for inbred mouse strains.},
  author={John S. Weber and Andrew G. Salinger and Monica J Justice},
  volume={26 4},
ENU is a powerful germline mutagen in the mouse, providing the opportunity to analyze the functions of large numbers of genes in the mammalian genome. In many mutagenesis experiments, it would be beneficial to exploit the advantages of inbred mouse strains. To perform an effective ENU mutagenesis screen using inbred mice, a dosage regimen is required to determine the optimal dose of ENU for that inbred strain, a time-consuming preliminary process. We have carried out dosage regimens for… CONTINUE READING

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