Optimal Intervention Strategies for Therapeutic Methods With Fixed-Length Duration of Drug Effectiveness

@article{Yousefi2012OptimalIS,
  title={Optimal Intervention Strategies for Therapeutic Methods With Fixed-Length Duration of Drug Effectiveness},
  author={Mohammadmahdi R. Yousefi and Aniruddha Datta and Edward R. Dougherty},
  journal={IEEE Transactions on Signal Processing},
  year={2012},
  volume={60},
  pages={4930-4944}
}
Intervention in gene regulatory networks in the context of Markov decision processes has usually involved finding an optimal one-transition policy, where a decision is made at every transition whether or not to apply treatment. In an effort to model dosing constraint, a cyclic approach to intervention has previously been proposed in which there is a sequence of treatment windows and treatment is allowed only at the beginning of each window. This protocol ignores two practical aspects of therapy… CONTINUE READING
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Finite Dynamic Programming: An Approach to Finite Markov Decision Processes

  • D. J. White
  • 1978
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