• Corpus ID: 244709358

Optimal Design of Experiments for Simulation-Based Inference of Mechanistic Acyclic Biological Networks

  title={Optimal Design of Experiments for Simulation-Based Inference of Mechanistic Acyclic Biological Networks},
  author={Vincent Zaballa and Elliot E Hui},
Biological signaling pathways based upon proteins binding to one another to relay a signal for genetic expression, such as the Bone Morphogenetic Protein (BMP) signaling pathway, can be modeled by mass action kinetics and conservation laws that result in non-closed form polynomial equations. Accurately determining parameters of biological pathways that represent physically relevant features, such as binding affinity of proteins and their associated uncertainty, presents a challenge for… 

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