Optimal Control for a Class of Compartmental Models in Cancer Chemotherapy

  title={Optimal Control for a Class of Compartmental Models in Cancer Chemotherapy},
  author={Andrzej Swierniak and Urszula Ledzewicz and Heinz Sch{\"a}ttler},
We consider a general class of mathematical models P for cancer chemotherapy described as optimal control problems over a fixed horizon with dynamics given by a bilinear system and an objective which is linear in the control. Several twoand three-compartment models considered earlier fall into this class. While a killing agent which is active during cell division constitutes the only control considered in the two-compartment model, Model A, also two three-compartment models, Models B and C, are… CONTINUE READING
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