Optimal Control Applied to Cell-cycle-specific

  title={Optimal Control Applied to Cell-cycle-specific},
  author={K. Renee Fister and John Carl Panetta},
We propose a mathematical model for the growth of cell-cycle-specific dose limiting bone marrow. In an attempt to determine effective methods of treatment without overdestruction of the bone marrow we implement optimal control theory. We design the control functional to maximize both the bone marrow mass and the dose over the treatment interval. Next we… CONTINUE READING