Optimal CD8 T-cell response against Encephalitozoon cuniculi is mediated by Toll-like receptor 4 upregulation by dendritic cells.

@article{Lawlor2010OptimalCT,
  title={Optimal CD8 T-cell response against Encephalitozoon cuniculi is mediated by Toll-like receptor 4 upregulation by dendritic cells.},
  author={Elizabeth M. Lawlor and Magali M. Moretto and Imtiaz A Khan},
  journal={Infection and immunity},
  year={2010},
  volume={78 7},
  pages={
          3097-102
        }
}
CD8+ T-cell immunity has been shown to play an important role in the protective immune response against Encephalitozoon cuniculi. Although earlier studies suggest that dendritic cells (DC) are important for the induction of this response, the factors responsible for initiation of the dendritic cell response against this pathogen have not been evaluated. In the current study, we demonstrate that E. cuniculi infection causes strong Toll-like receptor 4 (TLR4)-dependent dendritic cell activation… CONTINUE READING

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