Optically active trans-2-aminocyclopentanols: chemoenzymatic preparation and application as chiral ligands.


Optically active trans-2-(N,N-dialkylamino)cyclopentanols and their acetates derivatives were obtained with very good chemical yields and enantiomeric excesses (95->/=99%), through a chemoenzymatic methodology based on the lipase-catalyzed acylation of the hydroxyl group. The utility of these compounds was shown by the preparation of the cyclopentylic… (More)