Optical tweezers for measuring red blood cell elasticity: application to the study of drug response in sickle cell disease.

@article{Brando2003OpticalTF,
  title={Optical tweezers for measuring red blood cell elasticity: application to the study of drug response in sickle cell disease.},
  author={Marcelo M. Brand{\~a}o and A. Fontes and Maria de Lourdes Barjas-Castro and L. C. Barbosa and Fernando Ferreira Costa and Carlos L. Cesar and Sara Teresinha Ollala Saad},
  journal={European journal of haematology},
  year={2003},
  volume={70 4},
  pages={207-11}
}
The deformability of erythrocytes is a critical determinant of blood flow in microcirculation. By capturing red blood cells (RBC) with optical tweezers and dragging them through a viscous fluid we were able to measure their overall elasticity. We measured, and compared, the RBC deformability of 15 homozygous patients (HbSS) including five patients taking hydroxyurea (HU) for at least 6 months (HbSS/HU), 10 subjects with sickle cell trait (HbAS) and 35 normal controls. Our results showed that… CONTINUE READING