Optical suppression of drug-evoked phasic dopamine release

  title={Optical suppression of drug-evoked phasic dopamine release},
  author={J. E. McCutcheon and J. J. Cone and Christopher G. Sinon and S. M. Fortin and Pranish A. Kantak and Ilana B. Witten and K. Deisseroth and G. Stuber and M. Roitman},
  journal={Frontiers in Neural Circuits},
  • J. E. McCutcheon, J. J. Cone, +6 authors M. Roitman
  • Published 2014
  • Chemistry, Medicine
  • Frontiers in Neural Circuits
  • Brief fluctuations in dopamine concentration (dopamine transients) play a key role in behavior towards rewards, including drugs of abuse. Drug-evoked dopamine transients may result from actions at both dopamine cell bodies and dopamine terminals. Inhibitory opsins can be targeted to dopamine neurons permitting their firing activity to be suppressed. However, as dopamine transients can become uncoupled from firing, it is unknown whether optogenetic hyperpolarization at the level of the soma is… CONTINUE READING
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