Optical suppression of drug-evoked phasic dopamine release

@article{McCutcheon2014OpticalSO,
  title={Optical suppression of drug-evoked phasic dopamine release},
  author={J. E. McCutcheon and J. J. Cone and Christopher G. Sinon and S. M. Fortin and Pranish A. Kantak and Ilana B. Witten and K. Deisseroth and G. Stuber and M. Roitman},
  journal={Frontiers in Neural Circuits},
  year={2014},
  volume={8}
}
  • J. E. McCutcheon, J. J. Cone, +6 authors M. Roitman
  • Published 2014
  • Chemistry, Medicine
  • Frontiers in Neural Circuits
  • Brief fluctuations in dopamine concentration (dopamine transients) play a key role in behavior towards rewards, including drugs of abuse. Drug-evoked dopamine transients may result from actions at both dopamine cell bodies and dopamine terminals. Inhibitory opsins can be targeted to dopamine neurons permitting their firing activity to be suppressed. However, as dopamine transients can become uncoupled from firing, it is unknown whether optogenetic hyperpolarization at the level of the soma is… CONTINUE READING
    20 Citations
    Dopamine uptake dynamics are preserved under isoflurane anesthesia
    • 14
    A dopaminergic switch for fear to safety transitions
    • 58
    • PDF
    A descending dopamine pathway conserved from basal vertebrates to mammals
    • 38
    • PDF
    Estimating Neural Background Input with Controlled and Fast Perturbations: A Bandwidth Comparison between Inhibitory Opsins and Neural Circuits
    • D. Eriksson
    • Computer Science, Medicine
    • Front. Neural Circuits
    • 2016
    • 3
    • PDF

    References

    SHOWING 1-10 OF 61 REFERENCES
    Synaptic Overflow of Dopamine in the Nucleus Accumbens Arises from Neuronal Activity in the Ventral Tegmental Area
    • 216
    • PDF
    Subsecond dopamine release promotes cocaine seeking
    • 943
    • PDF
    Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
    • 1,028
    • PDF
    Disparity between tonic and phasic ethanol-induced dopamine increases in the nucleus accumbens of rats.
    • 80
    Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing.
    • 296
    Cannabinoids Enhance Subsecond Dopamine Release in the Nucleus Accumbens of Awake Rats
    • 287
    • PDF
    Differential Effects of Cocaine on Dopamine Neuron Firing in Awake and Anesthetized Rats
    • 52
    • PDF
    Amphetamine Paradoxically Augments Exocytotic Dopamine Release and Phasic Dopamine Signals
    • 124
    • PDF
    Ethanol directly excites dopaminergic ventral tegmental area reward neurons.
    • 348