Optical recording of action potentials with second-harmonic generation microscopy.

@article{Dombeck2004OpticalRO,
  title={Optical recording of action potentials with second-harmonic generation microscopy.},
  author={Daniel A Dombeck and Mireille Blanchard-Desce and Watt W. Webb},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 4},
  pages={
          999-1003
        }
}
Nonlinear microscopy has proven to be essential for neuroscience investigations of thick tissue preparations. However, the optical recording of fast (approximately 1 msec) cellular electrical activity has never until now been successfully combined with this imaging modality. Through the use of second-harmonic generation microscopy of primary Aplysia neurons in culture labeled with 4-[4-(dihexylamino)phenyl][ethynyl]-1-(4-sulfobutyl)pyridinium (inner salt), we optically recorded action… CONTINUE READING

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