Optical purity determination by NMR: use of chiral lanthanide shift reagents and a base line technique.

Abstract

A method for optical purity determination of a range of chiral drug molecules by NMR spectroscopy is reported. This technique involves the use of optically active lanthanide shift reagents and a newly developed base line analysis. Its applicability was demonstrated for a variety of drugs including nonsteroidal antiinflammatory agents and some adrenergic agents. It is established that successful application of the method depends on a constant shift reagent to sample molar ratio, constant instrumental conditions for all solutions, and the use of a calibration curve derived from solutions containing the same total concentration of the two enantiomers. For the examples cited, the correlation coefficient is not less than 0.97, and a mathematical treatment is included which supports the basis of the method.

Cite this paper

@article{Dewar1982OpticalPD, title={Optical purity determination by NMR: use of chiral lanthanide shift reagents and a base line technique.}, author={Gwen Dewar and Joseph Kwakye and Robert T. Parfitt and R. Sibson}, journal={Journal of pharmaceutical sciences}, year={1982}, volume={71 7}, pages={802-6} }