Optical pacing of the embryonic heart

  title={Optical pacing of the embryonic heart},
  author={Michael W. Jenkins and Austin R. Duke and Shi Gu and H. J. Chiel and Hisashi Fujioka and Michiko Watanabe and E. Duco Jansen and Andrew M. Rollins},
  booktitle={Nature photonics},
Light has been used to noninvasively alter the excitability of both neural and cardiac tissue 1-10. Recently, pulsed laser light has been shown to be capable of eliciting action potentials in peripheral nerves and in cultured cardiomyocytes 7-10. Here, we demonstrate for the first time optical pacing (OP) of an intact heart in vivo. Pulsed 1.875 μm infrared laser light was employed to lock the heart rate to the pulse frequency of the laser. A laser Doppler velocimetry (LDV) signal was used to… CONTINUE READING

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