Optical mapping reveals that repolarization spreads anisotropically and is guided by fiber orientation in guinea pig hearts.

@article{Kanai1995OpticalMR,
  title={Optical mapping reveals that repolarization spreads anisotropically and is guided by fiber orientation in guinea pig hearts.},
  author={Anthony J Kanai and Guy Salama},
  journal={Circulation research},
  year={1995},
  volume={77 4},
  pages={
          784-802
        }
}
Guinea pig hearts were stained with a voltage-sensitive dye and imaged on a photodiode array to record fluorescent action potentials (APs) from 124 sites. Activation and repolarization patterns were recorded from the epicardium during stimulation at different loci and correlated with the underlying fiber architecture. Endocardial APs were recorded by inserting a light guide into the ventricular cavity or by dissecting out the ventricular free wall to expose the endocardium. In hearts paced on… CONTINUE READING
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