Optical mapping of neuronal activity during seizures in zebrafish

  title={Optical mapping of neuronal activity during seizures in zebrafish},
  author={L Turrini and C Fornetto and G. Marchetto and Marie Caroline M{\"u}llenbroich and Natascia Tiso and Andrea Vettori and F Resta and Alessio Masi and Guido Mannaioni and F. S. Pavone and Francesco Vanzi},
  booktitle={Scientific Reports},
Mapping neuronal activity during the onset and propagation of epileptic seizures can provide a better understanding of the mechanisms underlying this pathology and improve our approaches to the development of new drugs. Recently, zebrafish has become an important model for studying epilepsy both in basic research and in drug discovery. Here, we employed a transgenic line with pan-neuronal expression of the genetically-encoded calcium indicator GCaMP6s to measure neuronal activity in zebrafish… CONTINUE READING
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