Optical mapping of DNA: single-molecule-based methods for mapping genomes.

@article{Neely2011OpticalMO,
  title={Optical mapping of DNA: single-molecule-based methods for mapping genomes.},
  author={Robert K. Neely and Jochem Deen and Johan Hofkens},
  journal={Biopolymers},
  year={2011},
  volume={95 5},
  pages={298-311}
}
The technologies associated with DNA sequencing are rapidly evolving. Indeed, single-molecule DNA sequencing strategies are cheaper and faster than ever before. Despite this progress, every sequencing platform to date relies on reading the genome in small, abstract fragments, typically of less than 1000 bases in length. The overarching aim of the optical map is to complement the information derived from DNA sequencing by providing long-range context on which these short sequence reads can be… CONTINUE READING

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