Optical mapping discerns genome wide DNA methylation profiles

@article{Ananiev2008OpticalMD,
  title={Optical mapping discerns genome wide DNA methylation profiles},
  author={Gene E. Ananiev and Steve Goldstein and Rod Runnheim and Dan K. Forrest and Shiguo Zhou and Konstantinos D. Potamousis and Chris Churas and Veit Bergendahl and James A. Thomson and David C. Schwartz},
  journal={BMC Molecular Biology},
  year={2008},
  volume={9},
  pages={68 - 68}
}
Methylation of CpG dinucleotides is a fundamental mechanism of epigenetic regulation in eukaryotic genomes. Development of methods for rapid genome wide methylation profiling will greatly facilitate both hypothesis and discovery driven research in the field of epigenetics. In this regard, a single molecule approach to methylation profiling offers several unique advantages that include elimination of chemical DNA modification steps and PCR amplification. A single molecule approach is presented… CONTINUE READING
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