Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress.

@article{Sah1999OpticalIR,
  title={Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress.},
  author={R. A. Sah and Rochelle D. Schwartz-Bloom},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 21},
  pages={9209-17}
}
The accumulation of reactive oxygen species (ROS) in the brain is associated with several neurodegenerative conditions. ROS can affect ionic homeostasis leading to impaired neurotransmission. Here, we determined the ability of H(2)O(2), a membrane permeant ROS, to alter intraneuronal Cl(-), an important regulator of neuronal excitability. Real-time alterations in intracellular chloride, [Cl(-)]i, were measured with UV laser scanning confocal microscopy in hippocampal slices loaded with the cell… CONTINUE READING
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