Optical imaging of tissue mitochondrial redox state in intact rat lungs in two models of pulmonary oxidative stress.

  title={Optical imaging of tissue mitochondrial redox state in intact rat lungs in two models of pulmonary oxidative stress.},
  author={R. Sepehr and Kevin S. Staniszewski and Sepideh Maleki and Elizabeth R. Jacobs and Said H. Audi and Mahsa Ranji},
  journal={Journal of biomedical optics},
  volume={17 4},
Ventilation with enhanced fractions of O(2) (hyperoxia) is a common and necessary treatment for hypoxemia in patients with lung failure, but prolonged exposure to hyperoxia causes lung injury. Ischemia-reperfusion (IR) injury of lung tissue is common in lung transplant or crush injury to the chest. These conditions are associated with apoptosis and decreased survival of lung tissue. The objective of this work is to use cryoimaging to evaluate the effect of exposure to hyperoxia and IR injury on… CONTINUE READING

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Pulmonary Vasculature Redox Signaling in Health and Disease

Advances in Experimental Medicine and Biology • 2017
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