Optical imaging of mammary and prostate tumors in living animals using a synthetic near infrared zinc(II)-dipicolylamine probe for anionic cell surfaces.

@article{Smith2010OpticalIO,
  title={Optical imaging of mammary and prostate tumors in living animals using a synthetic near infrared zinc(II)-dipicolylamine probe for anionic cell surfaces.},
  author={Bryan A. Smith and Walter J. Akers and W. Matthew Leevy and Andrew J. Lampkins and Shuzhang Xiao and William R. Wolter and Mark A. Suckow and Samuel Achilefu and Bradley D Smith},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 1},
  pages={67-9}
}
In vivo optical imaging shows that a fluorescent imaging probe, comprised of a near-infrared fluorophore attached to an affinity group containing two zinc(II)-dipicolylamine (Zn-DPA) units, targets prostate and mammary tumors in two different xenograft animal models. The tumor selectivity is absent with control fluorophores whose structures do not have appended Zn-DPA targeting ligands. Ex vivo biodistribution and histological analyses indicate that the probe is targeting the necrotic regions… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-5 of 5 references

Bioconjugate Chem 2008;19:686–692

  • WM Leevy, ST Gammon, +5 authors BD. Smith
  • J Am Chem Soc 2006;128:16476–16477
  • 2008

Radiology 2008;246:854–862

  • M Jennewein, MA Lewis, +12 authors PE. Thorpe
  • Clin Cancer Res 2008;14:1377–1385
  • 2008

Bioorg Med Chem 2005;13:5035–5042

  • RG Hanshaw, BD Smith
  • Coord Chem Rev 2006;250:3068–3080
  • 2006

Apoptosis 2005;10:731–741

  • JHW Distler, LC Huber, CF IIIReich, S Gay, O Distler, DS. Pisetsky
  • 2005

Nature Med 2008;14:1357–1362

  • MM Soares, SW King, PE. Thorpe
  • Cancer Res 2005;65:4408–4416
  • 2005

Similar Papers

Loading similar papers…