Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels

Abstract

Voltage-gated ion channels mediate electrical dynamics in excitable tissues and are an important class of drug targets. Channels can gate in sub-millisecond timescales, show complex manifolds of conformational states, and often show state-dependent pharmacology. Mechanistic studies of ion channels typically involve sophisticated voltage-clamp protocols… (More)
DOI: 10.7554/eLife.15202

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