Optical dissection of experience-dependent pre- and postsynaptic plasticity in the Drosophila brain.

@article{Pech2015OpticalDO,
  title={Optical dissection of experience-dependent pre- and postsynaptic plasticity in the Drosophila brain.},
  author={Ulrike Pech and Natalia H Revelo and Katharina J. Seitz and Silvio O Rizzoli and Andr{\'e} Fiala},
  journal={Cell reports},
  year={2015},
  volume={10 12},
  pages={
          2083-95
        }
}
Drosophila represents a key model organism for dissecting neuronal circuits that underlie innate and adaptive behavior. However, this task is limited by a lack of tools to monitor physiological parameters of spatially distributed, central synapses in identified neurons. We generated transgenic fly strains that express functional fluorescent reporters targeted to either pre- or postsynaptic compartments. Presynaptic Ca(2+) dynamics are monitored using synaptophysin-coupled GCaMP3, synaptic… CONTINUE READING
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