Optical control of GPR40 signalling in pancreatic β-cells† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01475a

Fatty acids activate GPR40 and K+ channels to modulate β-cell function. Herein, we describe the design and synthesis of FAAzo-10, a light-controllable GPR40 agonist based on Gw-9508. FAAzo-10 is a potent GPR40 agonist in the trans-configuration and can be inactivated on isomerization to cis with UV-A light. Irradiation with blue light reverses this effect… CONTINUE READING