Optical coherence tomography (OCT): a review

  title={Optical coherence tomography (OCT): a review},
  author={Joseph M. Schmitt},
  journal={IEEE Journal of Selected Topics in Quantum Electronics},
  • J. Schmitt
  • Published 1 July 1999
  • Physics
  • IEEE Journal of Selected Topics in Quantum Electronics
This paper reviews the state of the art of optical coherence tomography (OCT), an interferometric imaging technique that provides cross-sectional views of the subsurface microstructure of biological tissue. Following a discussion of the basic theory of OCT, an overview of the issues involved in the design of the main components of OCT systems is presented. The review concludes by introducing new imaging modes being developed to extract additional diagnostic information. 

Figures and Tables from this paper

Optical Coherence Tomography: A Concept Review

The history of OCT and its development throughout the last years is reviewed, and some research directions of recent and ongoing work concerned with the future developments of the technique and its application are listed.

Optical coherence tomography (Review)

The basic principles and possibilities of optical coherence tomography (OCT) as a method for the investigation of pathologies in medical diagnostics are outlined. We discuss the OCT method

Theory, developments and applications of optical coherence tomography

A number of different OCT techniques are discussed in some detail including time-domain, frequency- domain, full-field, quantum and Doppler OCT.

Polarization state analysis in optical coherence tomography

Optical Coherence Tomography (OCT) is a novel optical measurement technique for high resolution, high sensitivity 2D and 3D visualization of material inner structure. With the aid of OCT one can

Optical coherence tomography (OCT): new imaging modes for contrast enhancement

  • J. Schmitt
  • Physics
    1999 IEEE LEOS Annual Meeting Conference Proceedings. LEOS'99. 12th Annual Meeting. IEEE Lasers and Electro-Optics Society 1999 Annual Meeting (Cat. No.99CH37009)
  • 1999
Optical coherence tomography (OCT) combines the capabilities of confocal microscopy and low-coherence interferometry to provide high-resolution images of the internal microstructure of living tissue.

Optical Coherence Tomography (OCT) – An Emerging Technology for Three-Dimensional Imaging of Biological Tissues

Optical imaging technologies offer high resolution non-contact visualization of tissues with a large variety of contrast modalities. However tissues are optically inhomogeneous due to microscopic

A study on optimal interferometer topology of optical coherence tomography system

Using a simple Michelson interferometer, optical coherence tomography (OCT) system is possible to configure with low cost, small size and high resolution. By improving the performance of

Optical Coherence Tomography: Light Scattering and Imaging Enhancement 16

The fundamental aspects of optical coherence tomography and a brief description of its applications in medicine and biology are presented. The impact of multiple scattering in tissues on OCT imaging

Molecular contrast optical coherence tomography: a review.

The current state of research on the use of molecular contrast agents in optical coherence tomography (OCT) imaging techniques is reviewed, with an overview of the different molecular contrast OCT (MCOCT) methods that have been developed thus far.

Mathematical Methods of Optical Coherence Tomography

In this chapter a general mathematical model of Optical Coherence Tomography (OCT) is presented on the basis of the electromagnetic theory and an extension to standard OCT is briey presented.



Optical coherence tomography.

Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.

Contrast and resolution in optical coherence tomography

  • T. Hellmuth
  • Physics
    European Conference on Biomedical Optics
  • 1996
Optical coherence tomography (OCT) is an interferometric scanning technique. The instrument core is a Michelson interferometer comprising a moving reference mirror and a backscattering object

Optical coherence tomography.

The optical coherence tomograph is a new, noninvasive technical device that can obtain cross-sectional, high-resolution images-optical coherence tomographs (OCT)-of the retina. This instrument


Novel coherence-domain imaging techniques provide the capability for rapid, noninvasive imaging of microscopic sub-surface structures and blood flows in living biological tissues in order to provide the medical profession with new diagnostic tools.

Optical coherence tomography (OCT) of human skin with a slow-scan CCD camera

Investigation and improve the possibilities of optical coherence tomography for evaluation and imaging of the skin structure and dermatological diseases as melanoma and developments concerning a specially shaped fast detector head with on-line analogue data processing are presented.


A comprehensive model of optical coherence tomography (OCT) is described that includes the interference effects that produce speckle in images of dense heterogeneous tissue. It is based on the

In-vivo dual-beam optical coherence tomography

An in vivo partial coherence tomogram obtained from the optical nerve head of a human being is presented, demonstrating the inherent high precision and sensitivity of laser interferometry in this technique.

In vivo video rate optical coherence tomography.

An optical coherence tomography system is described which can image up to video rate and features a high speed scanning delay line in the reference arm based on Fourier-transform pulse shaping technology.

Low-coherence optical tomography in turbid tissue: theoretical analysis.

Theoretical analyses and preliminary experimental results suggest that, unlike time-resolving spectroscopy, low-coherence optical tomography detects the local relative variations of path-length-resolved reflectance from the turbid tissues.

Speckle in optical coherence tomography.

Four speckle-reduction methods-polarization diversity, spatialcompounding, frequency compounding, and digital signal processing-are discussed and the potential effectiveness of each method is analyzed briefly with the aid of examples.