Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and three-dimensional projection of the human enteric nervous system.

@article{Liu2011OpticalCI,
  title={Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and three-dimensional projection of the human enteric nervous system.},
  author={Y-A Liu and Yi-Wen Chen and A K I Chiang and S-J Peng and Pankaj Jay Pasricha and S-C Tang},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2011},
  volume={23 10},
  pages={
          e446-57
        }
}
BACKGROUND Due to the dispersed nature of neurites and fibers, the microtome-based 2-dimensional histology provides only a limited perspective of the enteric nervous system. To visualize the enteric plexus, we applied optical clearing to avoid scattering in the human ileum to facilitate photon penetration for 3-dimensional (3-D) microscopy of the neural tissue. METHODS Human ileal specimens were derived by trimming the donor bowel due to its excess length during the clinical trial of small… CONTINUE READING
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